CRTC1 and chronic myelogenous leukemia, BCR-ABL1 positive: As in studies of fibroblasts and solid tumor cell lines, we found that PP242 blocked rapamycin-resistant TORC1 and TORC2 signaling outputs in mouse and human leukemia cells representing either Ph+ B-precursor acute lymphoblastic leukemia (B-ALL) or chronic myeloid leukemia (CML).