NFE2L2 and cancer: In addition, anti-melanoma activity of orally administered CA was demonstrated recently in a murine xenograft model of the disease [18], and cinnamaldehydes (including CA and its 2-hydroxy- and 2-benzoyloxy-substituted analogs) that inhibit thioredoxin reductase and activate Nrf2 have been examined as potential candidates for cancer therapy and chemoprevention [19].