The HIFα transcription factors, HIF-1α and HIF-2α, mediate adaptive responses to tumor hypoxia, as well as regulating an extensive transcriptional response involving the induction of genes for angiogenesis, glucose metabolism/cellular energetics, cell growth, metastasis, apoptosis, and extracellular matrix (ECM) remodelling [1]. This evidence concerns the gene HIF1A and neoplasm.