DPP4 and type 2 diabetes mellitus: Since GLP-1 receptors have been identified in several tissues related with the cardiovascular system, such as the cardiomyocytes and vascular endothelial cells, the effects of the incretin-based therapies, such as the DPP-IV inhibitors, point to a potential benefit on attenuation of type-2 diabetes-induced cardiovascular complication [45].