In particular, adiponectin is a relevant anti-thrombotic adipokine, as widely reviewed [266, 268, 343] and emerging evidences underline ghrelin protective effects on insulin resistance, cardiovascular system, oxidative stress, and, likely, hemostatic balance [20, 104, 105, 343]: therefore, the reduced levels of this peptide in central obesity may be another deterimental feature increasing cardiovascular risk in obese subjects. This evidence concerns the gene GHRL and Insulin resistance.