VCAN and dengue disease: Repair and remodeling genes over-expressed in the DSS-gene signature also encode a diversity of molecules: the MMP-9, a matrix metalloprotease with key role in tissue remodeling and a candidate to dengue plasma leakage [47], the extracellular matrix molecules fibronectin, versican and collagens, the angiogenin and VEGF [17] endothelial agonists as well as the arginase 1 repair enzyme, which competes with the endothelial NOS (NOS3) for L-arginine biodisponibility [48].