This genome-wide expression analysis also confirms the over-expression of individual biomarkers previously associated with severe dengue, such as the acute phase pentraxin-related protein PTX3, the pro-inflammatory IL-18 cytokine or the anti-inflammatory IL-10 cytokine (Table S2) [11], [12], [15], providing a more comprehensive overview of their implication in the pathophysiology of DSS. This evidence concerns the gene IL18 and dengue disease.