When we performed immunohistochemical analysis of GPC3 in thyroid cancer [29], GPC3 was scarcely expressed in normal thyroid glands, but was dramatically enhanced in certain types of cancers including 100% of follicular carcinomas (20/20 cases) and 70% of papillary carcinomas (48/69 cases). This evidence concerns the gene GPC3 and papillary carcinoma.