When the average values of the reaction intensities (IRS scale) for tumours of different histological differentiation were compared by the Mann–Whitney U-test significant differences in UGT8 expression between malignancy grades G3 and G2 (P<0.01) as well as G3 and G1 (P<0.001) were found (Figure 2D). Here, UGT8 is linked to neoplasm.