In this context, it is worthwhile to remember that pivotal works from Cohen's group showed that, in B-CLL, TRAIL-R1 is predominantly expressed over TRAIL-R2, whereas no putative decoy receptors, TRAIL-R3 and TRAIL-R4, are present on the surface of B-CLL cells (MacFarlane et al, 2002, 2005). This evidence concerns the gene TNFRSF10D and B-cell chronic lymphocytic leukemia.