The aim of this study was to examine 10 polymorphisms in NOD1 (rs2075822, rs2907749 and rs2907748), NOD2 (rs5743260, rs2066844 and rs2066845), TLR2 (rs5743708), TLR4 (rs4986790) and TLR9 (rs5743836 and rs187084) to determine whether there was any association with endometrial cancer risk in an age and sex matched Caucasian population. The gene discussed is TLR2; the disease is endometrial cancer.