TNF and cancer: Several clinical investigations have been conducted to assess the predictive value of the genetic polymorphisms TNF-α G-308A, TNFRSF1A A36G and G-609T, and TNFRSF1B M196R/T587G, A1466G (or A1663G) and C1493T (or C1690T) regarding susceptibility to various inflammatory disorders [10-19], and recently, to cancer [23-28].