Clinical response was determined by T class (an index of tumor size, p = 0.002), N class (lymph node metastasis, p = 0.007), M class (distant metastasis, p = 0.001) and disease stage (p < 0.001), but TNFRSF1B A1466G genotype was independent of these factors. The gene discussed is TNFRSF1B; the disease is metastatic malignant neoplasm in the lymph nodes.