Clinical response was predicted by tumor size (p = 0,002), lymph node metastasis (p = 0.007), distant metastasis (p = 0.001) and disease stage (p < 0.001), but TNFRSF1B A1466G genotype was independent of these factors. The gene discussed is TNFRSF1B; the disease is metastatic malignant neoplasm in the lymph nodes.