Genes associated with EMT were regulated by TWIST1 in SNB19 and/or T98G GBM cells including extracellular matrix proteins fibronectin 1 (FN1) [14], periostin (POSTN) [15] and SPARC [16-18] protease MMP2 [19,20], transcription factor SNAI2 [21-23] transcriptional modifier ID1 [24], growth factor HGF [21,25] lysyl oxidase (LOX) [26] and cell adhesion protein cadherin 11 (CDH11) [27]. The gene discussed is TWIST1; the disease is glioblastoma.