Therefore, along with other transcription factors such as STAT3 and C/EBP which were recently identified as regulators of mesenchymal transformation in GBM cells [8] the correlation of TWIST1 with induction of mesenchymal changes, increased glioma grade and invasiveness implicate TWIST1 as an additional central regulator of this process in human GBM. The gene discussed is STAT3; the disease is central nervous system cancer.