To unravel the complex scenario of cerebral ischemia and to define the exact functional contribution of a particular K2P channel family member, further pharmacological and genetic tools are warranted, e.g. cell-type specific or conditional K2P3.1-/-, K2P9.1-/- or K2P10.1-/- mice. The gene discussed is KCNK10; the disease is Cerebral ischemia.