In 3 out of the 28 control patients with other neurodegenerative diseases (1 with Huntington's disease [HD]; 1 with Parkinson's disease [PD]; 1 with Alzheimer's disease [AD]), and in 2 of the 19 control patients without neurological disease, a few granular SOD1-immunoreactive inclusions were seen in some motoneurons (Figure 1C and L). This evidence concerns the gene SOD1 and Alzheimer disease.