As shown in Fig. 9K and 9L, the number of LRP-1-expressing cancer cells positive for talin-rich adhesion complexes was increased by about 1.4-fold under ERK inhibition (U0126 and dn-MEK) and by 1.7-fold under JNK activation (MKK-7/JNK-1). The gene discussed is MAPK1; the disease is cancer.