The engagement of Toll-like receptors (TLRs) on macrophages by pathogen-associated molecular patterns (PAMPs) leads to the generation of pro-inflammatory cytokines and mediators such as TNF, IL-6 and cyclo-oxygenase 2 (Cox2) which not only represent the acute response to infection or trauma but also shape pathogen-specific adaptive immune responses [1]. Here, PTGS2 is linked to infection.