NR4A1 and cancer: Using multivariate logistic regression analysis, hypermethylation of HIN-1 in lymph nodes metastases was significantly associated with ER positive cancers (odds ratio, 1.070; P = 0.024) and significantly associated with PR positive cancers (odds ratio, 1.046; P = 0.026), suggesting that methylation of HIN-1 gene may controlled by hormone receptors.