The initial discovery and replication (in an independent sample 1,728 white subjects) association studies (DNA level), along with subsequent gene expression analyses (RNA level), identified three single-nucleotide polymorphisms (SNPs) in the 3'-UTR of the fibroblast growth factor 2 (FGF2) gene as putative binding sites for miRNAs that may contribute to the risk of osteoporosis. This evidence concerns the gene FGF2 and osteoporosis.