After adrenalectomy, the serum concentration of TNF α R1 and TNF α R2 decreased in patients with Conn’s syndrome (1365.86 ± 156.51 vs. 2309.43 ± 736.86 pg/mL; p < 0.02 and 2587.71 ± 406.81 pg/mL vs. 3652.14 ± 956.62 pg/mL; p < 0.05 respectively) (Figures 4 and 6). This evidence concerns the gene TNFRSF1B and primary aldosteronism.