TNF and primary aldosteronism: They also proved, using immunoassay techniques, that the glomerular zone of the adrenal cortex is the site of the greatest synthesis of TNF α. The increased level of TNF α in our study in patients with Conn’s syndrome may confirm that the glomerular zone of the adrenal cortex mainly secretes TNF α. The secretion of TNF α by human adrenal glands confirmed the studies of González-Hernández et al. [19,20] and Päth et al. [21].