BRCA1 and breast cancer: In the present GWS for BC linkage in nine Icelandic non-BRCA1/2 families, substantial linkage signals were observed at chromosomes 2p25.1 to p22.1, 6q15 to q22.31 and 14q21.3 to q31.3, and the strongest contribution to all three regions occurred in the same family (70234).