CD40 and Cowden disease: A pattern of CD susceptibility similar to the one herein described for the polymorphism at −1 in CD40 was evidenced in the genome-wide study performed in CD by the Wellcome Trust Case Control Consortium [29], where rs4810485 (proxy of rs1883832, r2 = 0.95) was associated with CD [p = 0.009; OR (95%CI) = 1.14 (1.03–1.25)].