Moreover they found that hyperglycemia could trigger NF-κB activation and that dominant-negative IkBα could prevent COX-2 expression and apoptosis, implying that NF-κB activation can lead to COX-2 mediated PGE2 production and apoptosis in HUVECs exposed to hyperglycemia [96]. This evidence concerns the gene NFKB1 and Hyperglycemia.