IL18 and Granuloma: Conversely, P. acnes-primed Trif−/− mice, Caspase1−/− mice, Asc−/− mice and Nlrp3−/− mice all have normal dense granulomas in their livers, but fail to develop liver injury after LPS challenge, concomitant with the absence of the serum IL-18 increase (Table 3, Figure 7).