A genome wide admixture linkage scan followed by fine mapping recently identified MYH9, encoding non-muscle myosin heavy chain IIA, as a major susceptibility locus for focal segmental glomerulosclerosis (FSGS), HIV-associated collapsing glomerulosclerosis, also called HIV-associated nephropathy (HIVAN), and end stage kidney disease (ESKD) attributed to hypertension [1], [2]. The gene discussed is MYH9; the disease is focal segmental glomerulosclerosis.