SIRT1 and cancer: Our findings that miRNAs regulate SIRT1 expressionsuggest that inhibiting specific miRNAs may be of therapeutic value in diseaseconditions where SIRT1 activity has been shown to be beneficial such asdiabetes, neurodegeneration, and cancer [54].Currently available small molecule SIRT1 activators and inhibitors globallyincrease or inhibit SIRT1 activity.