The fact that both NO-susceptible and NO-resistant L. (V.)braziliensis isolates were maintained out to 120 hours of macrophage infection, even in the presence of LPS and IFN-γ (Figure 2), suggests that isolates can be resistant to other leishmanicidal mechanisms, including products of the NADPH oxidase (hydrogen peroxide, superoxide) [34-36]. The gene discussed is FMO5; the disease is infection.