The authors suggest that one week after transferrin injections, when transferrin levels have returned to baseline in hpx/hpx mice, “in spite of normalized hemoglobin levels...low transferrin levels lead to ineffective (iron-deficient) erythropoiesis.” [50] In fact, iron deficiency itself is associated with an increased rate of erythropoiesis and a preponderance of erythroid precursors that become quiescent without completing the maturation cycle [53]. The gene discussed is TF; the disease is nutritional disorder.