A recent analysis of cerebrospinal fluid (CSF) from first onset schizophrenia cases observed increased levels of S100B, without indications for impaired glial or neuronal cell integrity, as assessed by simultaneous measurement of non-secretory glial and neuronal proteins (glial fibrillary acidic protein/GFAP, myelin basic protein/MBP, neuron specific enolase/NSE) [13]. The gene discussed is S100B; the disease is schizophrenia.