Lately, new pharmacological properties of sponge secondary metabolites have been discovered, such as their capacity to inhibit the nuclear transcription factor-κB (NF-κB), which is one of the principal inducible transcriptional factors that plays a critical role in cancer development and in inflammation (see Folmer [6], for a review on NF-κB inhibitors). This evidence concerns the gene NFKB1 and cancer.