1F1E8hu recognizes the same antigen as Ob1A12 (a TcR isolated from a multiple sclerosis patient with a relapsing–remitting disease course; the Ob–MBP–DR2b complex structure shows a distinctive TcR binding mode positioned over the N-terminal portion of the MBP peptide) and the human TcR B7, which has a relatively high sequence identity to 1F1E8hu (59% and 56% for Vα and Vβ, respectively) and typifies foreign antigen-reactive TcRs in its pMHC-binding characteristics. The gene discussed is MBP; the disease is multiple sclerosis.