Castera L et al. [12] suggested that the combined use of FS and FT to assess liver fibrosis could avoid liver biopsy in most patients with chronic hepatitis C. In our study, although two of the three identified biomarkers, A2M and ApoAI, are the same as that in FT, ApoAI is decreased significantly only in advanced fibrosis (F3/F4). The gene discussed is APOA1; the disease is chronic hepatitis C virus infection.