To test whether the gene expression patterns that characterize Trp53ΔEC and RbΔEC; Trp53ΔEC mouse tumors (training dataset) are also present in human cancers with TP53 mutations and/or with poor clinical outcome, we performed an exhaustive comparison of the mouse tumor signature (682-probesets) with gene datasets of human cancer samples using the Oncomine human cancer genomics database (see Materials and Methods) [24,25]. The gene discussed is TP53; the disease is cancer.