TP53 and breast carcinoma: To study the existence of possible correlation with different types of p53 mutations in human tumors, we analyzed in further detail a breast cancer dataset containing gene expression and p53 mutation data of 247 patients [26], and which also showed the highest overlapping significance in the human p53-mutant tumors panel (asterisk in Fig. 4a) (98 overlapping genes, p-val = 1.6 × 10-66).