MMP3 and head and neck squamous cell carcinoma: On the other hand, significant difference was found in MMP-3 genotype distribution (6A/6A, 5A/5A and 5A/6A) between the areca nut with tobacco chewers and the non chewers both in OSMF (p = 0.02) and HNSCC (p = 0.003) patients vis-à-vis control group (p = 0.12) [Table 5 and 6].