Hence the anti-oxidative and anti-hyperglycemic effect of gold nanoparticles along with their protective effect over the organ damage during conditions of hyperglycemia induced oxidative stress may be attained through the inhibition of the stress signaling pathways or, due to the interaction of the AuNPs to the cystein-residues of the thioredoxin thereby preventing the inhibitor protein Txnip from binding to it during high glucose levels which is to be revealed yet. This evidence concerns the gene TXNIP and Hyperglycemia.