Another DbTg strain of mouse which over-expresses both the 695 amino acid isoform of human amyloid precursor protein (APP) with K670N and M671L mutations (APP695SWE mice) and the A246E mutation in PS1 (PS1A246E) has much more aggressive amyloidosis and plaque deposition than the APP695SWE mice [17]. Here, PSEN1 is linked to amyloidosis.