VKCFD is a heterogeneous coagulation disorder consisting of a deficiency of clotting factors II (FII), VII (FVII), IX (FIX), X (FX), as well as the coagulation inhibitors protein C (PC), protein S (PS) and protein Z (PZ). This evidence concerns the gene PROS1 and vitamin K-dependent clotting factors, combined deficiency of, type 1.