MTOR and familial pancreatic carcinoma: We investigated the role of mTOR inhibition and combined mTOR-EGFR inhibition in pancreatic cancer in the following two prospective clinical trials: Trial A, a phase II study of the mTOR-inhibitor, temsirolimus (CCI-779), and Trial B, a phase II study of the mTOR-inhibitor, everolimus (RAD001) + erlotinib combination.