Undefined factors trigger the aggregation of WT-SNCA within neurites and the cytoplasm of degenerating neurons to form so-called Lewy bodies and Lewy neurites which are microscopically visible in nearly all variants of PD, provoking the concept that SNCA oligomerization plays a key role in the neurodegenerative cascade [5]. The gene discussed is SNCA; the disease is Parkinson disease.