CCR5 and multiple sclerosis: Interestingly, while the CCR5-Δ32 polymorphism is rare among persons of Asian descent, the CCR2-64I-containing HHF*2 haplotype is very common, and has been associated with salutary effects (reduced risk) among persons of Japanese descent for several diseases with immunologic underpinnings including multiple sclerosis [55], sarcoidosis [56], and HIV [57].