Approximately 95% of LHON have one of three point mutations in the genes encoding subunits of the mitochondrial proton-translocating NADH-quinone oxidoreductase (complex I) which are G3460A (ND1), G11778A (ND4), and T14484C (ND6) [6]. This evidence concerns the gene MT-ND4 and Leber hereditary optic neuropathy.