Bioinformatics analyses of the genes commonly altered in Atxn1−/− and Atxn1154Q/+ cerebella show enrichment for categories associated with pathological pathways involved in neurodegeneration (Alzheimer's disease), and also pathways previously implicated in pathogenesis both in knock-in and transgenic SCA1 mouse models, such as the phosphatidylinositol and calcium signaling pathways [26]–[28]. The gene discussed is ATXN1; the disease is Alzheimer disease.