Ccnd1, one of the up-regulated genes that is potentially a direct target of Atxn1-Cic complexes (Figure 4A), and Igfbp5, an early key pathogenic marker in SCA1 disease (Figure 4B), were among the genes rescued by Atxn1L overexpression in Atxn1−/− mice. This evidence concerns the gene CIC and spinocerebellar ataxia type 1.