CXCL12 and acute myeloid leukemia: Recently, the “priming” concept in AML is reinforced by preclinical studies showing that the SDF-1 inhibitor Plerixafor (AMD3100), clinically developed as a mobilization agent for hematopoietic stem cell transplantation (HCT), sensitizes AML blasts to the effects of chemotherapy due to disruption of their interaction with the bone marrow microenviroment [43].