As DNMT3B is mediating de novo DNA methylation and thus epigenetically inactivates tumour suppressor genes in cancer (Robertson et al, 1999; Rhee et al, 2002; Lin et al, 2007), these observations connect blocked differentiation through CEBPA suppression with deregulated methylation because of the suppressed miR-29b activity. Here, DNMT3B is linked to cancer.