EGFR and neoplasm: The type of cell lines tested may also influence the sequence dependency of the findings with concurrent irradiation, as comparisons between models strongly and weakly expressing EGFR show that EGFR ‘strong’ cell lines exhibit both increased tumour growth delay after exposure to IR and a dual EGFR–VEGFR2 inhibition with paradoxical superiority of concomitant versus adjuvant sequencing in EGFR ‘weak’ cell lines (Gustafson et al, 2008).