EGFR and neoplasm: The aim of this study was to evaluate the effects of EGFR and VEGFR signalling inhibition on the response to radiotherapy, to determine whether scheduling of BMS-690514 and ionising radiation (IR) affected anti-tumour efficacy, to assess the influence of EGFR mutation on tumour response, and to investigate whether the effects of the treatments were related to changes in tumour perfusion and vasculature.