IGF2 and neoplasm: The IGF type 1 receptor (IGF-IR) pathway, initiated by the ligands IGF-1 and IGF-2, is associated with cellular mitogenesis, angiogenesis, tumour cell survival, and tumourigenesis in various tumour cell lines (Kalli et al, 2002; Kurmasheva and Houghton, 2006; Samani et al, 2007).