The aims of this study were to analyse: (1) the correlation between HER2 and MHC class I expressions in ESCC; (2) the relationship between the inhibition of HER2 signalling and expressions of MHC class I and APM components in ESCC; and (3) CTL function as a consequence of HER2 signal inhibition in ESCC. The gene discussed is ERBB2; the disease is esophageal squamous cell carcinoma.