Furthermore, even if ESCC cell lines (TE1, TE3, and KYSE30) were HER2 low-expressing cells (FISH negative), HER2 downregulation induced by HER2-siRNA transfection could upregulate total MHC class I and HLA-A2 expressions (Table 3). The gene discussed is ERBB2; the disease is esophageal squamous cell carcinoma.