For example, it was reported that there was an inverse correlation between HER2 and MHC class I expressions in murine tumour models (Lollini et al, 1998; Herrmann et al, 2004; Kaplan et al, 2006); in addition, the inverse correlation between HER2 and TAP expressions resulted in a reduced sensitivity to lysis by CTLs in human tumours (Herrmann et al, 2004). This evidence concerns the gene ERBB2 and neoplasm.