SFRP1 and Familial adenomatous polyposis: Of 26, 19 (73%) FAP adenomas and all of the sporadic adenomas showed a greater than 4-fold down-regulation of sFRP1. The magnitude of change was different, with sporadic adenomas showing greater down-regulation (median –973-fold, IQR −263 to −2990) than the FAP adenomas (median −7.2-fold, IQR −3 to −44).