Thus, the above mentioned neoneurogenesis - the innervation of tumor tissue - might facilitate pro-inflammatory events in two ways: either directly by the release of neurotransmitters that act on the tumor cells (e.g. substance P, bradykinin, calcitonin gene-related peptide) [9], or indirectly by an action on leukocytes that release such factors in response. Here, TAC1 is linked to neoplasm.