IGHG3 and infection: Serum samples from infected mice were analyzed for CRP-specific IgG isotype responses at day 28 post-infection, revealing a significant difference in the isotype profile of parasite specific IgG (p = 0.0006, 2-way ANOVA), with predominantly IgG1 and IgG2a produced in Balb/c, with a mixed response including IgG2b and IgG3 in C57Bl/6 mice (Fig 4B).