Therefore, we monitored the secretion of NGF and BDNF in Neo and Hsp72 cells after exposure to sublethal dose of either thapsigargin, tunicamycin, or 6-hydroxy dopamine (6-OHDA), a commonly used drug to mimic Parkinson's disease-like features in animals that also triggers ER stress [47],[48], to modulate ER physiology. The gene discussed is NGF; the disease is Parkinson disease.